SMURF2

SMURF2
Identifiers
Aliases	SMURF2, SMAD specific E3 ubiquitin protein ligase 2
External IDs	OMIM: 605532; MGI: 1913563; GeneCards: SMURF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZVD, 2DJY, 2JQZ, 2KXQ, 2LTZ
Enzyme activity
Gene location (Human)
Chr.	Chromosome 17 (human)
End	64,662,307 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,811,541 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; secondary oocyte; ; amniotic fluid; ; pylorus; ; saphenous vein; ; lactiferous duct; ; visceral pleura; ; pericardium; ; caput epididymis; ; Achilles tendon;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; secondary oocyte; ; zygote; ; left lung lobe; ; right lung lobe; ; endothelial cell of lymphatic vessel; ; genital tubercle; ; superior cervical ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; ubiquitin-protein transferase activity; transferase activity; ubiquitin protein ligase activity; transforming growth factor beta receptor binding; SMAD binding;
Cellular component	cytosol; membrane; ubiquitin ligase complex; plasma membrane; nucleoplasm; membrane raft; nuclear speck; nucleus; cytoplasm;
Biological process	positive regulation of canonical Wnt signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; BMP signaling pathway; positive regulation of trophoblast cell migration; ubiquitin-dependent SMAD protein catabolic process; regulation of transforming growth factor beta receptor signaling pathway; protein ubiquitination; negative regulation of transcription, DNA-templated; protein polyubiquitination; Wnt signaling pathway, planar cell polarity pathway; protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of BMP signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64750
	66313
	ENSG00000108854
	ENSMUSG00000018363
	Q9HAU4
	A2A5Z6
	NM_022739
	NM_025481; NM_001362894
	NP_073576
	NP_079757; NP_001349823
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene which is located at chromosome 17q23.3-q24.1.^[5]^[6]