SNRPB2

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesSNRPB2, Msl1, U2B'', small nuclear ribonucleoprotein polypeptide B2

External IDsOMIM: 603520; MGI: 104805; HomoloGene: 37728; GeneCards: SNRPB2; OMA:SNRPB2 - orthologs

Chr.Chromosome 20 (human)^[1]

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SNRPB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A9N
Identifiers
Aliases	SNRPB2, Msl1, U2B'', small nuclear ribonucleoprotein polypeptide B2
External IDs	OMIM: 603520; MGI: 104805; HomoloGene: 37728; GeneCards: SNRPB2; OMA:SNRPB2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p12.1 Start 16,729,961 bp[1] End 16,742,564 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G1 Start 142,904,959 bp[2] End 142,914,773 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ganglionic eminence Achilles tendon monocyte epithelium of nasopharynx skin of hip appendix islet of Langerhans superficial temporal artery Top expressed in medial ganglionic eminence abdominal wall primitive streak maxillary prominence mandibular prominence dermis otic placode ventricular zone cumulus cell embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding snRNA stem-loop binding protein binding RNA binding snRNP binding U1 snRNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex U2 snRNP small nuclear ribonucleoprotein complex fibrillar center nucleoplasm nuclear speck U1 snRNP U2-type catalytic step 2 spliceosome nucleus U2-type precatalytic spliceosome Biological process mRNA processing RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6629 20639 Ensembl ENSG00000125870 ENSMUSG00000008333 UniProt P08579 Q9CQI7 RefSeq (mRNA) NM_198220 NM_003092 NM_021335 RefSeq (protein) NP_003083 NP_937863 NP_067310 Location (UCSC) Chr 20: 16.73 – 16.74 Mb Chr 2: 142.9 – 142.91 Mb PubMed search [3] [4]
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The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.^[6]