SNX26

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.^[5][6][7]

AliasesARHGAP33, NOMA-GAP, SNX26, TCGAP, Rho GTPase activating protein 33

External IDsOMIM: 614902; MGI: 2673998; HomoloGene: 76448; GeneCards: ARHGAP33; OMA:ARHGAP33 - orthologs

Chr.Chromosome 19 (human)^[1]

End35,788,822 bp^[1]

Quick facts ARHGAP33, Identifiers ...

ARHGAP33
Identifiers
Aliases	ARHGAP33, NOMA-GAP, SNX26, TCGAP, Rho GTPase activating protein 33
External IDs	OMIM: 614902; MGI: 2673998; HomoloGene: 76448; GeneCards: ARHGAP33; OMA:ARHGAP33 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,774,532 bp[1] End 35,788,822 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 30,522,226 bp[2] End 30,535,060 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right uterine tube right hemisphere of cerebellum right frontal lobe C1 segment anterior pituitary right testis left testis right ovary Top expressed in superior frontal gyrus olfactory tubercle piriform cortex visual cortex primary visual cortex subiculum nucleus accumbens ganglionic eminence ventricular zone prefrontal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylinositol binding protein binding GTPase activator activity protein kinase binding Cellular component cytosol cytoplasm plasma membrane cell cortex actin cytoskeleton protein-containing complex dendritic spine Biological process regulation of small GTPase mediated signal transduction protein transport positive regulation of GTPase activity signal transduction small GTPase mediated signal transduction response to toxic substance regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115703 233071 Ensembl ENSG00000004777 ENSMUSG00000036882 UniProt O14559 Q80YF9 RefSeq (mRNA) NM_001172630 NM_052948 NM_001366178 NM_001289670 NM_001289682 NM_178252 RefSeq (protein) NP_001166101 NP_443180 NP_001353107 NP_001276599 NP_001276611 NP_839983 Location (UCSC) Chr 19: 35.77 – 35.79 Mb Chr 7: 30.52 – 30.54 Mb PubMed search [3] [4]
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This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The specific function of this protein has not been elucidated. Alternative splice variants have been described but their full length nature has not been determined.^[7]