In the mouse this gene is called SPEG complex locus.[9]
Expression of this gene is thought to serve as a marker for differentiated vascular smooth muscle cells which may have a role in regulating growth and differentiation of this cell type. The encoded protein is highly similar to the corresponding rat and mouse proteins. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of only one variant has been defined.
More information Mouse Mutant Alleles for Speg ...
Mouse Mutant Alleles for Speg
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI
Example structure of targeted conditional mutant allele for this gene
Molecular structure of Speg region with inserted mutation sequence
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Speg:
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Tam JL, Triantaphyllopoulos K, Todd H, Raguz S, de Wit T, Morgan JE, etal. (June 2006). "The human desmin locus: gene organization and LCR-mediated transcriptional control". Genomics. 87 (6): 733–746. doi:10.1016/j.ygeno.2006.01.009. PMID16545539.
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