SPIB

Protein that controls transcription of a set of genes in eukaryotes From Wikipedia, the free encyclopedia

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.[5][6]

AliasesSPIB, SPI-B, Spi-B transcription factor
End50,431,314 bp[1]
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SPIB
Identifiers
AliasesSPIB, SPI-B, Spi-B transcription factor
External IDsOMIM: 606802; MGI: 892986; HomoloGene: 79220; GeneCards: SPIB; OMA:SPIB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003121
NM_001243998
NM_001243999
NM_001244000

NM_019866

RefSeq (protein)

NP_001230927
NP_001230928
NP_001230929
NP_003112

NP_063919

Location (UCSC)Chr 19: 50.42 – 50.43 MbChr 7: 44.18 – 44.18 Mb
PubMed search[3][4]
Wikidata
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Function

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM][6]

Interactions

SPIB has been shown to interact with MAPK3[7] and MAPK8.[7]

References

Further reading

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