Spartan (SPRTN) is a protein that in humans is encoded by the SPRTN gene. It is involved in DNA repair.[5][6][7] Mutations in the SPRTN gene Ruijs-Aalfs syndrome is an autosomal recessive genetic disorder. Characteristics of this disorder are features of premature aging, chromosome instability and development of hepatocellular carcinoma.[8] Ruijs-Aalfs syndrome arises as a result of mutations in the SPRTN gene that encodes a metalloproteinase employed in the repair of protein-linked DNA breaks.[8]
AliasesSPRTN, C1orf124, DDDL1880, DVC1, PRO4323, Spartan, dJ876B10.3, SprT-like N-terminal domain Quick facts Available structures, PDB ...
Close
SPRTN stands for SprT-domain at the N terminus, and the name comes from the E. coli gene SprT (stationary phase regulated). The gene SprT was named in 1996 by Dr. Ryutaro Utsumi, whose team identified the gene while searching for regulators of the bolA1 transcriptional regulator in the stationary phase.[9]
