SRD5A3

SRD5A3
Identifiers
Aliases	SRD5A3, CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1, steroid 5 alpha-reductase 3
External IDs	OMIM: 611715; MGI: 1930252; HomoloGene: 41385; GeneCards: SRD5A3; OMA:SRD5A3 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 4 (human)
End	55,373,100 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	76,303,351 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; gallbladder; ; olfactory zone of nasal mucosa; ; mucosa of esophagus; ; body of pancreas; ; skin of thigh; ; gingival epithelium; ; gonad; ; C1 segment; ; epithelium of nasopharynx;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; secondary oocyte; ; zygote; ; primary oocyte; ; internal carotid artery; ; yolk sac; ; lip; ; external carotid artery; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; cholestenone 5-alpha-reductase activity; oxidoreductase activity; 3-oxo-5-alpha-steroid 4-dehydrogenase activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; polyprenol reductase activity;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	lipid metabolism; polyprenol catabolic process; androgen biosynthetic process; protein glycosylation; dolichol metabolic process; dolichyl diphosphate biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; dolichol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	79644
	57357
	ENSG00000128039
	ENSMUSG00000029233
	Q9H8P0
	Q9WUP4
	NM_024592
	NM_020611
	NP_078868
	NP_065636
	Wikidata
View/Edit Human	View/Edit Mouse

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.^[5]^[6] It is one of three forms of 5α-reductase. Unlike SRD5A1 and SRD5A2, SRD5A3 has no apparent form in androgen processing or signaling. Instead, SRD5A3 reduces polyprenol to dolichol, which is necessary for N-linked glycosylation of proteins and some lipids.^[7]