In the early 1900s, the Clan Line operated two main routes between United Kingdom and her colonies in the East. One was a direct route from the home ports through the Strait of Gibraltar, Suez Canal and to the ports of India and Ceylon. The other involved sailing down the western coast of Africa first to the ports of South African colonies; then onto the ports of Ceylon and India; and occasional trips to Australia.
Upon delivery, Clan Alpine went to Middlesbrough, and thence to Glasgow for loading, where she arrived on 18 November 1899. From there, she sailed to Liverpool and Manchester to load more cargo. She left Manchester for Bombay for her maiden voyage on 12 December 1899,[5] passing through Suez Canal on 30 December, and arrived in Bombay on 13 January 1900.[6] After calling at several Indian ports, she left for Britain, passed through Suez Canal on 13 February, and reached Dunkirk on 3 March.[7] After unloading, she continued to Britain, and arrived at Greenock on 15 March.[8] After a brief stop, she left Greenock on 22 March 1900, loaded cargo at Liverpool, and left there for Cape Town on 29 March.[9][10] After calling at various South African ports, she sailed to Ceylon via Mauritius, and arrived at Galle on 3 July.[11] From Galle she continued to India, including Madras, where she arrived on 28 July. From India, Clan Alpine left for Britain via Colombo, and arrived in London on 8 September 1900,[12] before continuing to Glasgow which she reached on 22 September.[13] She soon left for another trip, leaving from Liverpool for Calcutta on 6 October 1900.[14]
Clan Alpine continued service on both routes through the rest of her career.
On 22 November 1908, Clan Alpine left Liverpool for South Africa.[15] On 11 December 1908 it was announced that Clan Alpine was chartered to take wheat from South Australia to England and Europe.[16] She reached Cape Town on 19 December 1908 from Liverpool;[17] left there on 23 December; called at Mossel Bay and Port Elizabeth; and reached East London on 31 December 1908.[18] She left East London on 2 January 1909, reached Adelaide on 23 January 1909, and continued to Geelong[19] where she arrived three days later.[20]
On 10 June 1917, U-60 sank Clan Alpine by torpedo, 40 nautical miles (74 km) off Muckle Flugga, Shetland Islands on a passage from Tyne to Archangel, killing eight members of her crew.