SULF2
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.[5][6]
External IDsOMIM: 610013; MGI: 1919293; HomoloGene: 10313; GeneCards: SULF2; OMA:SULF2 - orthologs
Function
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM][6]
