SULT1E1

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesSULT1E1, EST, EST-1, ST1E1, STE, sulfotransferase family 1E member 1

External IDsOMIM: 600043; MGI: 98431; HomoloGene: 101388; GeneCards: SULT1E1; OMA:SULT1E1 - orthologs

Chr.Chromosome 4 (human)^[1]

Quick facts Available structures, PDB ...

SULT1E1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G3M, 1HY3, 4JVL, 4JVM, 4JVN
Identifiers
Aliases	SULT1E1, EST, EST-1, ST1E1, STE, sulfotransferase family 1E member 1
External IDs	OMIM: 600043; MGI: 98431; HomoloGene: 101388; GeneCards: SULT1E1; OMA:SULT1E1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 69,841,212 bp[1] End 69,860,145 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E1|5 43.56 cM Start 87,723,828 bp[2] End 87,739,453 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in human penis right adrenal gland buccal mucosa cell left adrenal cortex right adrenal cortex skin of leg jejunal mucosa skin of abdomen duodenum olfactory zone of nasal mucosa Top expressed in olfactory epithelium efferent ductule seminal vesicula decidua subcutaneous adipose tissue spermatocyte submandibular gland white adipose tissue parotid gland tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function estrone sulfotransferase activity transferase activity sulfotransferase activity steroid binding steroid sulfotransferase activity flavonol 3-sulfotransferase activity protein binding lipid binding aryl sulfotransferase activity Cellular component cytoplasm cytosol nuclear membrane Biological process steroid metabolic process positive regulation of fat cell differentiation estrogen metabolic process sulfation ethanol catabolic process estrogen catabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6783 20860 Ensembl ENSG00000109193 ENSMUSG00000029272 UniProt P49888 P49891 Q9D566 RefSeq (mRNA) NM_005420 NM_023135 RefSeq (protein) NP_005411 NP_075624 Location (UCSC) Chr 4: 69.84 – 69.86 Mb Chr 5: 87.72 – 87.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.^[6]