SUSPUP and SUSPPUP
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0.6–5.3 (SUSPPUP)
| SUSPUP and SUSPPUP | |
|---|---|
| Synonyms | (serum sodium to urinary sodium to serum potassium to urinary potassium) and (serum sodium to urinary sodium to serum potassium2 to urinary potassium) |
| Reference range | 3.6–22.6 (SUSPUP) 0.6–5.3 (SUSPPUP) |
| Test of | Extent of hormonal stimulation of sodium absorption and potassium excretion in kidney's tubules and collecting tubes |
SUSPUP (serum sodium to urinary sodium to serum potassium to urinary potassium) and SUSPPUP (serum sodium to urinary sodium to (serum potassium)2 to urinary potassium) are calculated structure parameters of the renin–angiotensin-aldosterone system (RAAS). They have been developed to support screening for primary or secondary aldosteronism.[1][2]
The steroid hormone aldosterone stimulates the reabsorption of sodium and the excretion of potassium in the distal tubuli and the collecting tubes of the kidneys. Calculating SUSPUP and/or SUSPPUP helps to determine the intensity of mineralocorticoid signalling, which may be helpful in the differential diagnosis of hypertension and hypokalaemia.[citation needed]
Preconditions of testing
Sodium and potassium concentrations have to be determined in serum and spot urine probes that have been obtained simultaneously or within a short time interval between.[citation needed]
![{\displaystyle SUSPUP={\frac {\frac {{[Na}^{+}]_{Serum}}{{[Na}^{+}]_{Urine}}}{\frac {{[K}^{+}]_{Serum}}{{[Na}^{+}]_{Urine}}}}}](https://wikimedia.org/api/rest_v1/media/math/render/svg/ff322d3b37775950da214594b2711926a761e6e8)
![{\displaystyle SUSPPUP={\frac {\frac {{[Na}^{+}]_{Serum}}{{[Na}^{+}]_{Urine}}}{\frac {{[K}^{+}]_{Serum}^{2}}{{[Na}^{+}]_{Urine}}}}}](https://wikimedia.org/api/rest_v1/media/math/render/svg/14315aa4c62995aacd8055e6f1ac2209796cb9ae)