SW222746

Drug class15-PGDH inhibitor

CAS Number

• 2241676-74-2

PubChem CID

• 135300446

ChemSpider

• 128921368

SW222746

Clinical data
Drug class	15-PGDH inhibitor
Identifiers
IUPAC name 2-methyl-6-[7-(piperidine-1-carbonyl)quinoxalin-2-yl]isoquinolin-1-one
CAS Number	2241676-74-2
PubChem CID	135300446
ChemSpider	128921368
ChEMBL	ChEMBL5220884
PDB ligand	RLD (PDBe, RCSB PDB)
Chemical and physical data
Formula	C24H22N4O2
Molar mass	398.466 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1C=CC2=C(C1=O)C=CC(=C2)C3=CN=C4C=CC(=CC4=N3)C(=O)N5CCCCC5
InChI InChI=1S/C24H22N4O2/c1-27-12-9-16-13-17(5-7-19(16)24(27)30)22-15-25-20-8-6-18(14-21(20)26-22)23(29)28-10-3-2-4-11-28/h5-9,12-15H,2-4,10-11H2,1H3 Key:URHPFANOQLIROT-UHFFFAOYSA-N

SW222746 is a drug which acts as a potent inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH). It increases levels of prostaglandin E2 and stimulates tissue regeneration, and has good oral bioavailability.^[1] It has been researched in animal studies for treatment of muscle wasting in the elderly.^[2][3]