SYCP3

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Synaptonemal complex protein 3 is a protein that in humans is encoded by the SYCP3 gene.[5][6][7] It is a component of the synaptonemal complex formed between homologous chromosomes during the prophase of meiosis.[8]

PDBOrtholog search: PDBe RCSB
AliasesSYCP3, COR1, SCP3, SPGF4, RPRGL4, synaptonemal complex protein 3
Quick facts Available structures, PDB ...
SYCP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSYCP3, COR1, SCP3, SPGF4, RPRGL4, synaptonemal complex protein 3
External IDsOMIM: 604759; MGI: 109542; HomoloGene: 7964; GeneCards: SYCP3; OMA:SYCP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001177948
NM_001177949
NM_153694

NM_011517

RefSeq (protein)

NP_001171419
NP_001171420
NP_710161

NP_035647

Location (UCSC)Chr 12: 101.73 – 101.74 MbChr 10: 88.3 – 88.31 Mb
PubMed search[3][4]
Wikidata
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Gene family

More information XLR/SYCP3/FAM9 domain, Identifiers ...
XLR/SYCP3/FAM9 domain
Identifiers
SymbolCor1
PfamPF04803
InterProIPR006888
CATH4cpc
Available protein structures:
PDB  IPR006888 PF04803 (ECOD; PDBsum)  
AlphaFold
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SYCP3 is also known as COR1. It contains a conserved coiled-coil domain that is also found in the FAM9 (FAM9A, FAM9B) family of proteins, found on the human X chromosome.[5]

Several SYCP3-like proteins are found on mice sex chromosomes. They are assigned names starting with Slx or Sly depending on the chromosome they are linked to. Slx/Slxl1 and Sly are neofunctionalized ones that have opposite effects on gene expression and epigenetic modifications, and each gene reduces the viability and mobility (via spindlin binding) of sperms containing the other sex chromosome, tilting the sex ratio to their own favor.[9] Over time they are duplicated to balance out each other's effects.[10]

References

Further reading

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