Salinosporamide

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The salinosporamides are a group of closely related chemical compounds isolated from marine bacteria in the genus Salinispora.[1][2][3][4] They possess a densely functionalized γ-lactam-β-lactone bicyclic core.

Salinosporamide A has attracted interest for its potential use in treating various types of cancer.[5][6][7][8]

In addition, a variety of synthetic analogs have been prepared.[9]

Chemical structures

References

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