Salivary duct carcinoma
From Wikipedia, the free encyclopedia
| Salivary duct carcinoma | |
|---|---|
 | |
| Low magnification micrograph of a salivary duct carcinoma with characteristic comedonecrosis (left of image) adjacent to normal parotid gland (right of image). H&E stain. | |
| Specialty | ENT surgery |
Salivary duct carcinoma (SDC) is a rare type of aggressive cancer that arises from the salivary glands.[1] It is predominantly seen in men and, generally, has a poor prognosis.[2] Other high grade carcinomas can mimic SDC. About 40-60% of SDC arise in pleomorphic adenomas.[3] Most, if not all, SDCs express androgen receptor by immunohistochemistry.[4] Therapeutically relevant genetic alterations include ERBB2/Her2 amplification, PIK3CA and/or HRAS mutations.[5][6]
The typical presentation is a rapidly growing mass with associated pain.[2] This may be seen in association with neck lymph node swelling (cervical lymphadenopathy), due to metastases, and facial nerve paralysis.
Diagnosis
SDC are diagnosed by examination of tissue, e.g. a biopsy.
Their histologic appearance is similar to ductal breast carcinoma.
Very low mag.
Intermed. mag.
Very high mag.
