Salmefamol

Salmefamol (INNTooltip International Nonproprietary Name, BANTooltip British Approved Name; developmental code name AH-3923) is a drug of the phenethylamine and amphetamine families described as a bronchodilator which was never marketed.^[2] It is a β-adrenergic receptor agonist with some selectivity for the β₂-adrenergic receptor^[3][4] and has been described as a "sister compound" to salbutamol.^[5] However, the drug is more potent (1.5-fold), longer-acting (6 hours), and more lipophilic in comparison to salbutamol.^[6][1] It was intended for inhalational or intravenous administration.^[1] Salmefamol was first described in the literature by 1968.^[2]

Other namesAH-3923; AHR-3929; 1-(4-hydroxy-3-(hydroxymethyl)phenyl)-2-(4-methoxy-α-methylphenethylamino)ethanol

Routes of
administrationInhalation, intravenous^[1]

Drug classBronchodilator; β-Adrenergic receptor agonist

CAS Number

• 18910-65-1

Quick facts Clinical data, Other names ...

Salmefamol

Clinical data
Other names	AH-3923; AHR-3929; 1-(4-hydroxy-3-(hydroxymethyl)phenyl)-2-(4-methoxy-α-methylphenethylamino)ethanol
Routes of administration	Inhalation, intravenous[1]
Drug class	Bronchodilator; β-Adrenergic receptor agonist
Identifiers
IUPAC name 4-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]-2-(hydroxymethyl)phenol
CAS Number	18910-65-1
PubChem CID	86805
ChemSpider	78303
UNII	Q56SEY8X9J
KEGG	C11771
ChEMBL	ChEMBL2107072
CompTox Dashboard (EPA)	DTXSID80864864
Chemical and physical data
Formula	C19H25NO4
Molar mass	331.412 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)CO)O
InChI InChI=1S/C19H25NO4/c1-13(9-14-3-6-17(24-2)7-4-14)20-11-19(23)15-5-8-18(22)16(10-15)12-21/h3-8,10,13,19-23H,9,11-12H2,1-2H3 Key:VPMWDFRZSIMDKW-UHFFFAOYSA-N

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