Hamadeh began his career as an associate at the Los Angeles management consulting firm L.E.K. Consulting,[3] where he focused on corporate and business strategy. Before that, he co-founded and managed a customized textbook printing company, worked at Chevron Corporation, and co-authored The Internship Bible and America’s Top Internships published by Random House's Princeton Review imprint.[4]
In 1996, Hamadeh co-founded Vault.com and served as CEO[5] until the company was sold to the New York private equity firm Veronis Suhler Stevenson in October 2007.[6] His Vault.com co-founders were Mark Oldman and his late brother H.S. “Sam” Hamadeh.[7]
Hamadeh sits on the board of the non-profit PeaceWorks Foundation[8] and is or has been a board observer, angel investor and advisor in two dozen early-stage companies, including Directly, Campusfood.com (sold to GrubHub Seamless[9]), Crunched, Splurgy, and PublicStuff (now part of Accela[10]).[3] Samer is also a mentor at several accelerators, including German Accelerator,[11] Lazaridis Institute,[12] Blueprint Health, NYCSeedStart, and First Growth Venture Network, as well as a member of Young Presidents' Organization[3] and the Executive Board of Venture for America.[13]