The Via dei Pettinari retraces the route of an ancient path which starts from the Pons Aurelius and headed towards the Theatre of Pompey. A church at the site was present by the 12th century, and is mentioned in a bull by Pope Honorius II in 1127. It was dedicated under the title "Transfiguration of our Lord Jesus Christ". The Transfiguration was depicted in the apse by Filippo Prosperi. Between the windows, in each of the eight quadrants divided by pilasters on the dark red wall, Prósperi also frescoed, on gold, saints and patriarchs of the Old Testament that foreshadowed the Savior. The suffix in onda derives from the frequent floods (inondazione) of the district by the Tiber river.[1]
By 1260, a church was erected and placed under the ownership of a monastic order of Paul of Thebes, the first Christian hermit.[2] In January 1445, the church and adjacent convent were then ceded to the Conventual Franciscans by Pope Eugene IV, and in 1844, Pope Gregory XVI ceded the church to a new order organized by Vincenzo Pallotti.[1] The campanile has two bells of 1850 to replace the previous, seized by the Roman Republic in 1848. The church underwent reconstruction in 1867, including elevation, directed by Luca Carimini, who used a basilica design. The work was funded by the Cassetta brothers, Antonio and Pietro as the Pallottines could not then afford it.[3] The church was reopened August 6, 1878, by a mass presided over by Msgr. Francesco di Paola Cassetta.
The church is divided by twelve pillars into three naves. In the center of the apse is a fresco depicting Virgin and Child (1878) by Cesare Mariani, which replaced the picture of the Queen of the Apostles by Serafino Cesaretti. Under the main altar is a sarcophagus made by Arnoldo Brandizzi which, since 1950, contains the body of St Vincent Pallotti.[1]
The Lady Chapel of the Virgo Potens opens to the right nave. The chapel was erected in the last century by the Cassetta family. On the altar is the picture of the “Virgo Potens” donated by the Venerable Elisabetta Sanna, who died in 1857 and was buried in this chapel. The Stations of the Cross were made by Domenico Cassarotti. The organ is the work of Pietro Pantanella.
Below the presbytery of the church, there is a crypt, dating probably to the eighth century. Under the crypt, below the level of the city are wine cellars and storerooms of Roman times.[4]
Pope John Paul II visited the church on June 22, 1986.[5] He had stayed at the Generalate House for some weeks in 1946 while a student in Rome.[4]