Božić received the 186th position on the Progressive Party's Aleksandar Vučić — Future We Believe In electoral list in the 2014 parliamentary election. The list won a majority victory with 158 out of 250 seats; Božić was not elected and did not serve in assembly that followed.[4] She received the 144th position on the successor Aleksandar Vučić — Future We Believe In electoral list in the 2016 election.[5] The list won 131 mandates, and she was once again not immediately elected; she was, however, awarded a mandate on 6 March 2018, as a replacement for Vesna Rakonjac.[6]
During the 2016–20 parliament, Božić was a member of the assembly committee on the rights of the child and the committee on labour, social issues, social inclusion, and poverty reduction; a deputy member of the defence and internal affairs committee, the health and family committee, and the committee on administrative, budgetary, mandate, and immunity issues; a substitute member of Serbia's delegation to the Parliamentary Dimension of the Central European Initiative; and a member of the parliamentary friendship groups with Austria, Azerbaijan, China, Germany, Ghana, Greece, Portugal, Russia, Sweden, and the United States of America.[7]
Božić and fellow Progressive Party parliamentarian Aleksandar Martinović went on a two-day hunger strike in May 2020, to protest the inaction of Serbia's prosecution and judiciary against what they described as the violent behaviour of Dveri leader Boško Obradović.[8] The strike ended after President Vučić urged the parliamentarians to call it off.[9]
She was promoted to the seventeenth position on the Progressive Party's Aleksandar Vučić — For Our Children list for the 2020 Serbian parliamentary election[10] and was elected to a second term when the list won a landslide victory with 188 mandates. After the election, she was chosen as deputy leader of the Aleksandar Vučić — For Our Children parliamentary group. She is also the chair of the culture and information committee; a full member of the committee on administrative, budgetary, mandate, and immunity issues; a deputy member of the security services control committee; a member of the European Union–Serbia stabilization and association committee; the leader of Serbia's parliamentary friendship group with the United Kingdom; and a member of the parliamentary friendship groups with China, France, Germany, Ireland, Italy, Japan, Morocco, Russia, Spain, Sweden, Turkey, the United Arab Emirates, and the United States of America.[11]
On May 8, 2024, Sandra Božić was elected as Deputy Prime Minister of the Provincial Government of Vojvodina.[12]