Santa Luzia was probably built for the General Company of Brazil [pt].
On 21 February 1650, off Cabo de Santo Agostinho, Santa Luzia, under the command of Bernardo Ramires Esquível, was attacked by a squadron of nine Dutch ships, commanded by Caspar Govertsz Cop.[1] Santa Luzia defended himself with a violent artillery duel, that lasted until the night.[1] After the combat, Santa Luzia anchored near the coast, in order to take care of the wounded and repair the damage suffered.[1]
On 22 February, in the morning, the combat returned. Maneuvering ably, Esquível did not cease fire on the Dutch ships that approached the Santa Luzia, causing a lot of damage and casualties.[1] Possibly because they did not have enough soldiers, the Dutch ships did not attempt to board the Santa Luzia. By the mid-afternoon, having come to the conclusion that the could not defeat the Santa Luzia, Cop put an end to the fight by retreating to the north.[1]
Santa Luzia's fate after this is unknown.