The church was built in early medieval centuries at the site of a rustic Ancient Roman villa. It remained a parish church until 1409, when it was made part of a Gesuati Convent. The entrance to the church is striking because it is approached by a long external stone staircase rising to a 16th-century sculpted portal in a wall. From there, a narrow passage between tall bushes lead to the facade portico. Inside the portico, in the lunette above the entrance, is a fresco of the Annuciation (1561) completed by the brothers Lorenzo and Bartolomeo Torresani.
The church has a single nave. In the left apse is a fresco depicting the Marriage of the Virgin attributed to Alessandro Torresani, son of Lorenzo. In the left transept are 16th-century terracotta statues depicting Mary and Joseph and a nativity scene (presepe). In the chapel on the left, on the right, is a fresco depicting the Last Judgement by the Torresani brothers.
In the central apse is a polychrome statue of the Madonna and Child (1489), signed by Carlo l'Aquilano. The 15th-century frescoes depict the Madonna and Child and on the ceiling, Christ in a Mandorla.
In the right apse is a 15th-century polychrome crucifix. Two paintings depict Saint John the Baptist and St Sebastian, painted by followers of Antoniazzo Romano, they are painted on a reliquary built into the wall.
The Gesuati order was suppressed in 1668, and the convent was closed.[1]
