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Sarizotan

Chemical compound From Wikipedia, the free encyclopedia

Sarizotan (EMD-128,130) is a selective 5-HT1A receptor agonist and D2 receptor antagonist,[1] which has antipsychotic effects,[2][3] and has also shown efficacy in reducing dyskinesias resulting from long-term anti-Parkinsonian treatment with levodopa.[4][5][6][7]

Pregnancy
category
  • N/A
Routes of
administrationOral
ATC code
  • none
Legal status
  • Discontinued
Quick facts Clinical data, Pregnancycategory ...
Sarizotan
Clinical data
Pregnancy
category
  • N/A
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • Discontinued
Identifiers
  • 1-[(2R)-3,4-dihydro-2H-chromen-2-yl]-N-([5-(4-fluorophenyl)pyridin-3-yl]methyl)methanamine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H21FN2O
Molar mass348.421 g·mol−1
3D model (JSmol)
  • C1CC2=CC=CC=C2O[C@H]1CNCC3=CN=CC(=C3)C4=CC=C(C=C4)F
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In June 2006, the developer Merck KGaA announced that the development of sarizotan was discontinued, after two sarizotan Phase III studies (PADDY I, PADDY II) failed to meet the primary efficacy endpoint and neither the Phase II findings nor the results from preclinical studies could be confirmed. No statistically significant difference of the primary target variable between sarizotan and placebo could be demonstrated.[8][9]

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