SerBut

SerBut, also known as O-butyryl-L-serine or as seryl-butyrate, is an ester conjugate of the short-chain fatty acid butyric acid (butyrate) and the amino acid serine.^{[1][2][3][4][5]} It is a prodrug of butyric acid with high oral bioavailability and enhanced blood–brain barrier permeability in animals.^[1][2][4][5] The drug makes use of amino acid transporters for absorption and transport.^[3][4] It shows anti-inflammatory effects in rodents including in models of autoimmune diseases and neuroinflammation.^[1][2][4][5] The use of butyric acid itself is hindered by its rapid metabolism in the gastrointestinal tract and other limitations.^[4] The chemical synthesis of SerBut has been described.^[4] SerBut was first described in the scientific literature by 2024.^[1][2][4][5]

Other namesO-Butyryl-L-serine; O-Butanoyl-L-serine; Serine–butyrate conjugate; Seryl-butyrate

Drug classButyric acid prodrug

ATC code

• None

CAS Number

• 63321-66-4

Quick facts Clinical data, Other names ...

SerBut

Clinical data
Other names	O-Butyryl-L-serine; O-Butanoyl-L-serine; Serine–butyrate conjugate; Seryl-butyrate
Drug class	Butyric acid prodrug
ATC code	None
Identifiers
IUPAC name (2S)-2-amino-3-butanoyloxypropanoic acid
CAS Number	63321-66-4
PubChem CID	11651229
ChemSpider	9825967
Chemical and physical data
Formula	C7H13NO4
Molar mass	175.184 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCC(=O)OC[C@@H](C(=O)O)N
InChI InChI=1S/C7H13NO4/c1-2-3-6(9)12-4-5(8)7(10)11/h5H,2-4,8H2,1H3,(H,10,11)/t5-/m0/s1 Key:HTDGDRZVMBNEMO-YFKPBYRVSA-N

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