Nyasiase modeled locally in Kenya before being discovered.[4] She made her fashion week runway debut during the F/W 2017 season, walking for Miu Miu, Rick Owens, and Armani.[5] In 2018, she walked for Tom Ford, Jason Wu, Marc Jacobs, Burberry, Erdem, Mulberry, Gucci, Marni, Versace, Rochas, Dries Van Noten and Kenzo among others.[6]
Nyasiase notably closed the S/S 2019 Balenciaga show.[4]
She has appeared in advertisements for Versace, Alexander McQueen, Marc Jacobs, and Issey Miyake.[6]
She currently ranks on the “Hot List” by models.com.[7] British Vogue listed her as one of the Top Models of London Fashion Week.[8]
For a Vogue video about South Sudanese models, Nyasiase described how the Trump travel ban affects her career.[9]