Siah interacting protein N-terminal domain
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| Siah-Interacting Protein, N terminal domain | |||||||||
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 NMR structure of N-terminal domain (residues 1-77) of Siah-interacting protein. | |||||||||
| Identifiers | |||||||||
| Symbol | Siah-Interact_N | ||||||||
| Pfam | PF09032 | ||||||||
| InterPro | IPR015120 | ||||||||
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In molecular biology the protein domain, Siah interacting protein N-terminal domain is found at the N-terminal of the protein, Siah interacting protein (SIP). It has a helical hairpin structure with a hydrophobic core which is further stabilised by an arrangement of side chains contributed by the two amphipathic helices. The function of this domain remains to be fully elucidated, but it is known to be vital for interactions with Siah. It has also been hypothesised that SIP can dimerise through this N-terminal domain.[1]