Sicarius ornatus

The venom of Sicarius ornatus contains active sphingomyelinase D, the main toxin responsible for local and systemic effects, the venom of S. ornatus is endowed with all toxic properties in vitro and ex vivo, and like Loxosceles, it is capable and hydrolyzes sphingomyelin, induce cell death of keratinocytes and complement-dependent hemolysis, harmful events that have been associated with the presence of active sphingomyelinase D and pathologies in vivo, these studies indicate that the venom of S. ornatus can potentially lead to a pathology similar to that of Loxosceles.^[1] Five micrograms of venom can induce more than 60% of hemolysis, while Sicarius tropicus causes a maximum 50% of hemolysis even at higher concentrations.^[2]