Silandrone

Silandrone
Clinical data
Other names	Testosterone 17β-trimethylsilyl ether; Testosterone O-trimethylsilyl ether; 17β-Trimethylsilyltestosterone; O-Trimethylsilyltestosterone; 17β-(trimethylsiloxy)androst-4-en-3-one; SC-16148; NSC-95147
Routes of; administration	By mouth, intramuscular injection, subcutaneous injection
Identifiers
	IUPAC name (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-17-trimethylsilyloxy-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one;
CAS Number	5055-42-5;
PubChem CID	68627;
ChemSpider	61886 ;
UNII	YY7GL3CCE9;
KEGG	D05837;
ChEBI	CHEBI:607921;
ChEMBL	ChEMBL485687;
CompTox Dashboard (EPA)	DTXSID60884126 ;
ECHA InfoCard	100.023.414
Chemical and physical data
Formula	C22H36O2Si
Molar mass	360.613 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O[Si](C)(C)C)CCC4=CC(=O)CC[C@]34C;
	InChI InChI=1S/C22H36O2Si/c1-21-12-10-16(23)14-15(21)6-7-17-18-8-9-20(24-25(3,4)5)22(18,2)13-11-19(17)21/h14,17-20H,6-13H2,1-5H3/t17-,18-,19-,20-,21-,22-/m0/s1; Key:HNZDTAXZHUDITM-WLNPFYQQSA-N;

Silandrone (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name) (developmental code name SC-16148), also known as testosterone 17β-trimethylsilyl ether or 17β-trimethylsilyltestosterone, as well as 17β-(trimethylsiloxy)androst-4-en-3-one, is a synthetic anabolic-androgenic steroid (AAS) and an androgen ether – specifically, the 17β-trimethylsilyl ether of testosterone – which was developed by the G. D. Searle & Company in the 1960s but was never marketed.^[1] It has a very long duration of action when given via subcutaneous or intramuscular injection, as well as significantly greater potency than that of testosterone propionate.^[2]^[3] In addition, silandrone, unlike testosterone and most esters of testosterone like testosterone propionate, is orally active.^[4]

Other namesTestosterone 17β-trimethylsilyl ether; Testosterone O-trimethylsilyl ether; 17β-Trimethylsilyltestosterone; O-Trimethylsilyltestosterone; 17β-(trimethylsiloxy)androst-4-en-3-one; SC-16148; NSC-95147

Routes of
administrationBy mouth, intramuscular injection, subcutaneous injection

CAS Number

5055-42-5

PubChem CID

68627

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Silandrone

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Clinical data

Other names	Testosterone 17β-trimethylsilyl ether; Testosterone O-trimethylsilyl ether; 17β-Trimethylsilyltestosterone; O-Trimethylsilyltestosterone; 17β-(trimethylsiloxy)androst-4-en-3-one; SC-16148; NSC-95147
Routes of administration	By mouth, intramuscular injection, subcutaneous injection
Identifiers
IUPAC name (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-17-trimethylsilyloxy-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
CAS Number	5055-42-5
PubChem CID	68627
ChemSpider	61886^Y
UNII	YY7GL3CCE9
KEGG	D05837
ChEBI	CHEBI:607921
ChEMBL	ChEMBL485687
CompTox Dashboard (EPA)	DTXSID60884126
ECHA InfoCard	100.023.414
Chemical and physical data
Formula	C₂₂H₃₆O₂Si
Molar mass	360.613 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O[Si](C)(C)C)CCC4=CC(=O)CC[C@]34C
InChI InChI=1S/C22H36O2Si/c1-21-12-10-16(23)14-15(21)6-7-17-18-8-9-20(24-25(3,4)5)22(18,2)13-11-19(17)21/h14,17-20H,6-13H2,1-5H3/t17-,18-,19-,20-,21-,22-/m0/s1 Key:HNZDTAXZHUDITM-WLNPFYQQSA-N