SirReal2

SirReal2
Clinical data
Drug class	Sirtuin 2 (SIRT2) inhibitor
Identifiers
	IUPAC name 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide;
CAS Number	709002-46-0;
PubChem CID	1096292;
ChemSpider	934777;
ChEMBL	ChEMBL3770903;
Chemical and physical data
Formula	C22H20N4OS2
Molar mass	420.55 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC4=CC=CC=C43)C;
	InChI InChI=1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27); Key:MENNDDDTIIZDDN-UHFFFAOYSA-N;

SirReal2 is a drug which acts as a potent and selective sirtuin 2 (SIRT2) inhibitor. It inhibits SIRT2 with an IC₅₀ of 140nM, and is selective over SIRT1, SIRT3 and SIRT5. It is used in research into cancer, inflammation and neurodegenerative disorders such as Parkinson's disease, and has led to the discovery of a number of related derivatives.^[1]^[2]^[3]^[4]^[5]^[6]^[7]