Sitneprotafib

Drug classSHP2 inhibitor

CAS Number

• 2245082-05-5

PubChem CID

• 142434183

FormulaC₂₁H₂₂ClN₇S

Sitneprotafib

Clinical data
Drug class	SHP2 inhibitor
Identifiers
IUPAC name (5S)-1'-[5-[(2-amino-3-chloro-4-pyridinyl)sulfanyl]pyrazin-2-yl]spiro[5,7-dihydrocyclopenta[b]pyridine-6,4'-piperidine]-5-amine
CAS Number	2245082-05-5
PubChem CID	142434183
Chemical and physical data
Formula	C21H22ClN7S
Molar mass	439.97 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CN(CCC12CC3=C([C@H]2N)C=CC=N3)C4=CN=C(C=N4)SC5=C(C(=NC=C5)N)Cl
InChI InChI=1S/C21H22ClN7S/c22-18-15(3-7-26-20(18)24)30-17-12-27-16(11-28-17)29-8-4-21(5-9-29)10-14-13(19(21)23)2-1-6-25-14/h1-3,6-7,11-12,19H,4-5,8-10,23H2,(H2,24,26)/t19-/m1/s1 Key:GKGIGIUNYOFYHZ-LJQANCHMSA-N

Sitneprotafib (JAB-3312) is a drug that acts as an inhibitor of the protein tyrosine phosphatase enzyme SHP-2 (PTPN11). It has been researched for the treatment of cancer and is in clinical trials as a combination treatment with glecirasib.^[1][2][3]