Sodium-dependent multivitamin transporter

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.^[5][6][7]

AliasesSLC5A6, SMVT, solute carrier family 5 member 6, NERIB

External IDsOMIM: 604024; MGI: 2660847; GeneCards: SLC5A6

Chr.Chromosome 2 (human)^[1]

End27,212,958 bp^[1]

Quick facts SLC5A6, Identifiers ...

SLC5A6
Identifiers
Aliases	SLC5A6, SMVT, solute carrier family 5 member 6, NERIB
External IDs	OMIM: 604024; MGI: 2660847; GeneCards: SLC5A6
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 27,199,587 bp[1] End 27,212,958 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,193,380 bp[2] End 31,206,268 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right testis left testis right frontal lobe placenta right hemisphere of cerebellum body of uterus left uterine tube right ovary corpus epididymis Top expressed in choroid plexus of fourth ventricle morula morula yolk sac Epithelium of choroid plexus blastocyst right kidney Ileal epithelium neural layer of retina dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function symporter activity sodium-dependent multivitamin transmembrane transporter activity transmembrane transporter activity Cellular component vesicle membrane integral component of membrane brush border membrane plasma membrane integral component of plasma membrane membrane Biological process ion transport sodium ion transport biotin transport pantothenate transmembrane transport transmembrane transport biotin metabolic process pantothenate metabolic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 8884 330064 Ensembl ENSG00000138074 ENSMUSG00000006641 UniProt Q9Y289 Q5U4D8 RefSeq (mRNA) NM_021095 NM_001177621 NM_001177622 NM_177870 NM_001360022 RefSeq (protein) NP_066918 NP_001171092 NP_001171093 NP_808538 NP_001346951 Location (UCSC) Chr 2: 27.2 – 27.21 Mb Chr 5: 31.19 – 31.21 Mb PubMed search [3] [4]
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The SMVT is a transporter for pantothenic acid (vitamin B5) and biotin (vitamin B7) at the blood–brain barrier.^[8] It is also a transporter for lipoic acid^[9] and iodide. Transport of these nutrients is competitive^[10] and a surplus of a given nutrient may saturate the transporter and prevent the uptake of other nutrients.