Solute carrier family 10 member 4

AliasesSLC10A4, P4, solute carrier family 10 member 4

External IDsMGI: 3606480; HomoloGene: 15495; GeneCards: SLC10A4; OMA:SLC10A4 - orthologs

Chr.Chromosome 4 (human)^[1]

End48,489,526 bp^[1]

SLC10A4
Identifiers
Aliases	SLC10A4, P4, solute carrier family 10 member 4
External IDs	MGI: 3606480; HomoloGene: 15495; GeneCards: SLC10A4; OMA:SLC10A4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p11 Start 48,483,343 bp[1] End 48,489,526 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.2 Start 73,164,226 bp[2] End 73,170,298 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pars reticulata pars compacta testicle pituitary gland superior vestibular nucleus anterior pituitary endothelial cell prefrontal cortex Hypothalamus putamen Top expressed in neural tube striatum of neuraxis morula anterior horn of spinal cord Mesencephalon adrenal gland superior frontal gyrus embryo rhombencephalon autonomic nervous system More reference expression data BioGPS n/a
Gene ontology Molecular function symporter activity bile acid:sodium symporter activity Cellular component integral component of membrane plasma membrane membrane integral component of synaptic vesicle membrane dopaminergic synapse cholinergic synapse serotonergic synapse Biological process ion transport transmembrane transport sodium ion transport bile acid and bile salt transport adult behavior regulation of neurotransmitter loading into synaptic vesicle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 201780 231290 Ensembl ENSG00000145248 ENSMUSG00000029219 UniProt Q96EP9 Q3UEZ8 RefSeq (mRNA) NM_152679 NM_173403 RefSeq (protein) NP_689892 NP_775579 Location (UCSC) Chr 4: 48.48 – 48.49 Mb Chr 5: 73.16 – 73.17 Mb PubMed search [3] [4]
Wikidata
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Solute carrier family 10 member 4 is a protein that in humans is encoded by the SLC10A4 gene.^[5] In mice, it appears to promote acidification of synaptic vesicles containing monoamines, enhancing their uptake, and is co-expressed with VMAT2 and VAChT.^[6]