Spondin 1

SPON1
Identifiers
Aliases	SPON1, VSGP/F-spondin, f-spondin, Spondin 1
External IDs	OMIM: 604989; MGI: 2385287; GeneCards: SPON1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZOT, 2ZOU, 3COO, 3Q13
Gene location (Human)
Chr.	Chromosome 11 (human)
End	14,268,133 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	113,642,605 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; mucosa of sigmoid colon; ; pericardium; ; lower lobe of lung; ; cardia; ; mucosa of urinary bladder; ; external globus pallidus; ; right lung; ; visceral pleura; ; parietal pleura;
	Top expressed in
	epithelium of lens; ; iris; ; ciliary body; ; external carotid artery; ; cervix; ; internal carotid artery; ; retinal pigment epithelium; ; atrium; ; decidua; ; suprachiasmatic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; extracellular matrix structural constituent; LBD domain binding;
Cellular component	extracellular matrix; extracellular region; endoplasmic reticulum lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	cell adhesion; protein O-linked fucosylation; positive regulation of protein processing; positive regulation of protein binding; negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10418
	233744
	ENSG00000262655
	ENSMUSG00000038156
	Q9HCB6
	Q8VCC9
	NM_006108
	NM_145584
	NP_006099
	NP_663559
	Wikidata
View/Edit Human	View/Edit Mouse

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.^[5] It is secreted by cells of the floor plate and may be involved in axon guidance^[6] The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.