The orphanage was established to care for female orphans in the local area in 1776.[1] It was located in Hampstead Road where the foundation stone for premises completely rebuilt to a design by E. W. Hudson was laid by Lord Southampton on 28 January 1904.[1]
After the trustees of the orphanage vacated the building, the former orphanage was acquired by the National Temperance Hospital for use as an annex in 1945.[2] The ground floor was subsequently converted for medical use.[3] Following the closure of the National Temperance Hospital in 1990, the former orphanage became the home of the Margarete Centre which provides support to sufferers of substance abuse.[4]
The archives of the orphanage are now held at the Highgate Literary and Scientific Institution.[5]
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