Piagno played college softball at the University of Tampa.[3] On July 23, 2015, Piagno threw the first no-hitter in women's baseball at the Pan American Games, in Toronto,[4] defeating the Puerto Rico women's national baseball team.[3] In June 2016, she was signed by the Sonoma Stompers of the Pacific Association of Professional Baseball Clubs. This made her and fellow Stompers teammate outfielder-pitcher Kelsie Whitmore the first women to play professional baseball as teammates since the 1950s.[3]
On July 1, 2016, Piagno made her professional debut against the San Rafael Pacifics.
On July 15, 2017, Piagno recorded a win against the Pittsburg Diamonds in her first start of the 2017 season. In doing so, she became the third woman since the 1950s to win a game in an American men's professional league.[5]
Piagno also had an 11 inning scoreless streak from July 15 until August 19. She ended the season with a 1–0 record and a 4.20 ERA
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