Sterigmatocystin 8-O-methyltransferase
From Wikipedia, the free encyclopedia
Sterigmatocystin 8-O-methyltransferase (EC 2.1.1.110) is an enzyme that catalyzes the chemical reaction
| Sterigmatocystin 7-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.110 | ||||||||
| CAS no. | 116958-29-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This is a methylation reaction in which the aflatoxin, sterigmatocystin, is converted to its methyl ether, 8-O-methylsterigmatocystin. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Aspergillus parasiticus.[1]
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This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase. Other names in common use include sterigmatocystin methyltransferase, O-methyltransferase II, sterigmatocystin 7-O-methyltransferase (incorrect), S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase, and (incorrect).[2] It is part of the biosynthetic pathway to aflatoxin B1.[3]
