Sticky platelet syndrome
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| Sticky platelet syndrome | |
|---|---|
| Specialty | Hematology |
Sticky platelet syndrome (SPS) is a heritable disorder of platelet function in which platelet hyperaggregation leads to hypercoagulability.[1][2][3][4][5] It was first described by Mammen in 1983.[6] It is inherited in an autosomal dominant pattern.[7] It has not been associated with a specific gene, and it is not recognized as an entity in OMIM.
It can present in conjunction with protein S deficiency and factor V Leiden.[8] It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder.
SPS has not been widely studied[9] and is not widely known.[10]
Symptoms are related to hypercoagulability,[9] usually presenting as venous thromboembolisms, arterial thrombosis,[9] myocardial infarction, angina, and stroke.[1]
Cause
The syndrome is believed to be hereditary.[11]