Stratifin

Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans.^[5][6] The protein is named for its presence in stratified epithelial cells.^[5]

PDBOrtholog search: PDBe RCSB

AliasesSFN, YWHAS, Stratifin

External IDsOMIM: 601290; MGI: 1891831; HomoloGene: 4475; GeneCards: SFN; OMA:SFN - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts SFN, Available structures ...

SFN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YWT, 1YZ5, 3IQJ, 3IQU, 3IQV, 3LW1, 3MHR, 3O8I, 3P1N, 3P1O, 3P1P, 3P1Q, 3P1R, 3P1S, 3SMK, 3SML, 3SMM, 3SMN, 3SMO, 3SPR, 3T0L, 3T0M, 3U9X, 3UX0, 4DAT, 4DAU, 4DHM, 4DHN, 4DHO, 4DHP, 4DHQ, 4DHR, 4DHS, 4DHT, 4DHU, 4FL5, 4FR3, 4HQW, 4HRU, 4IEA, 4JC3, 4JDD, 4QLI, 5HF3, 4Y5I, 4Y32, 4Y3B, 3SP5
Identifiers
Aliases	SFN, YWHAS, Stratifin
External IDs	OMIM: 601290; MGI: 1891831; HomoloGene: 4475; GeneCards: SFN; OMA:SFN - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 26,863,149 bp[1] End 26,864,456 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.3|4 66.25 cM Start 133,327,867 bp[2] End 133,329,479 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium hair follicle mucosa of pharynx nipple vulva skin of thigh human penis skin of hip oral cavity body of tongue Top expressed in lip esophagus blastocyst morula skin of abdomen skin of external ear transitional epithelium of urinary bladder skin of back intestinal villus cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding phosphoprotein binding protein binding protein kinase binding protein kinase C inhibitor activity identical protein binding cadherin binding Cellular component extracellular region extracellular exosome cytoplasmic vesicle membrane nucleus mitochondrion extracellular space cytoplasm cytosol Biological process regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of keratinocyte proliferation negative regulation of protein kinase activity establishment of skin barrier keratinization keratinocyte differentiation regulation of cell cycle positive regulation of protein export from nucleus positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway keratinocyte development positive regulation of cell growth regulation of epidermal cell division intrinsic apoptotic signaling pathway in response to DNA damage membrane organization positive regulation of epidermal cell differentiation signal transduction release of cytochrome c from mitochondria skin development negative regulation of protein serine/threonine kinase activity DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2810 55948 Ensembl ENSG00000175793 ENSMUSG00000047281 UniProt P31947 O70456 RefSeq (mRNA) NM_006142 NM_018754 RefSeq (protein) NP_006133 NP_061224 Location (UCSC) Chr 1: 26.86 – 26.86 Mb Chr 4: 133.33 – 133.33 Mb PubMed search [3] [4]
Wikidata
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