Sulfalene

Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.^[2][3] As of 2014 there were only two countries in which it is currently still marketed: Thailand and Ireland.^[3]

Trade namesEadazine, Kelfizina, Kelfizine W, Longum

Other namesSulfametopyrazine

AHFS/Drugs.comInternational Drug Names

Routes of
administrationOral^[1]

Quick facts Clinical data, Trade names ...

Sulfalene

Clinical data
Trade names	Eadazine, Kelfizina, Kelfizine W, Longum
Other names	Sulfametopyrazine
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral[1]
ATC code	J01ED02 (WHO) QJ01EQ19 (WHO)
Pharmacokinetic data
Protein binding	60 to 80%[1]
Elimination half-life	60 to 65 hours[1]
Excretion	Urinary[1]
Identifiers
IUPAC name 4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide
CAS Number	152-47-6 Y
PubChem CID	9047
DrugBank	DB00664 Y
ChemSpider	8695 Y
UNII	T6BL4ZC15G
KEGG	D01216 Y
CompTox Dashboard (EPA)	DTXSID2046179
ECHA InfoCard	100.005.278
Chemical and physical data
Formula	C11H12N4O3S
Molar mass	280.30 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(=O)(Nc1nccnc1OC)c2ccc(N)cc2
InChI InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) Y Key:KXRZBTAEDBELFD-UHFFFAOYSA-N Y
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It was discovered by researchers at Farmitalia and first published in 1960 and was marketed as Kelfizina.^[4][5]