Sulfanegen

Sulfanegen is an experimental antidote for cyanide poisoning.^[1] It is being studied as a prodrug for 3-mercaptopyruvic acid (3-MP). 3-MP has been studied as a potential treatment for cyanide poisoning, but the half-life is too short for it to be clinically effective.^[2] Instead, alternative chemicals such as sulfanegen, the hemithioacetal cyclic dimer of 3-MP, are being evaluated that produce 3-MP in vivo to compensate for the short half-life of 3-MP itself.^[3]

Quick facts Names, Identifiers ...

Sulfanegen

Names
IUPAC name 2,5-Dihydroxy-1,4-dithiane-2,5-dicarboxylic acid
Identifiers
CAS Number	80003-64-1 (Na+ salt) Y 1309654-46-3
3D model (JSmol)	Interactive image
ChEBI	CHEBI:138170
ChemSpider	29395474
PubChem CID	24830990
UNII	14338V25RC Y
CompTox Dashboard (EPA)	DTXSID301045729
InChI InChI=1S/C6H8O6S2/c7-3(8)5(11)1-13-6(12,2-14-5)4(9)10/h11-12H,1-2H2,(H,7,8)(H,9,10) Key: GYZMXMSJOZUNEQ-UHFFFAOYSA-N InChI=1/C6H8O6S2/c7-3(8)5(11)1-13-6(12,2-14-5)4(9)10/h11-12H,1-2H2,(H,7,8)(H,9,10) Key: GYZMXMSJOZUNEQ-UHFFFAOYAO
SMILES C1C(SCC(S1)(C(=O)O)O)(C(=O)O)O
Properties
Chemical formula	C6H8O6S2
Molar mass	240.24 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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Sulfanegen has been shown to be effective in animal studies.^[4] It is being studied as the disodium salt, sulfanegen sodium,^[3][5] and the triethanolamine salt, sulfanegen TEA.^[6] One advantage various sulfanegen formulations have over existing treatments for acute cyanide poisoning is that they might be administered by intramuscular injection or orally^[1] rather than by intravenous infusion.^[6]