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Sulfate adenylyltransferase (ADP)

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Sulfate adenylyltransferase (ADP) (EC 2.7.7.5) is an enzyme that catalyzes the first of two chemical reactions that convert adenosine diphosphate to 3'-phosphoadenosine-5'-phosphosulfate, a coenzyme in sulfotransferase reactions.[1]

+ SO2−4
 
 
 
Reversible left-right reaction arrow with minor forward product(s) to top right and minor reverse substrate(s) from bottom right
 
Pi
 
2D representation of the chemical structure of Q356138.
adenosine 5′-phosphosulfate

The enzyme characterised from yeast combines adenosine diphosphate with sulfate ion, giving phosphate (Pi) as a byproduct.[2][3]

This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ADP:sulfate adenylyltransferase. Other names in common use include ADP-sulfurylase, sulfate (adenosine diphosphate) adenylyltransferase, and adenosine diphosphate sulfurylase.[4]

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