Sulforidazine

Typical antipsychotic medication From Wikipedia, the free encyclopedia

Sulforidazine (Imagotan, Psychoson, Inofal) a typical antipsychotic and a metabolite of thioridazine; it and mesoridazine are more potent than the parent compound, whose pharmacological effects are believed by some to be largely due to its metabolism into sulforidazine and mesoridazine.[1]

ATC code
  • none
CAS Number
PubChem CID
ChemSpider
Quick facts Clinical data, ATC code ...
Sulforidazine
Clinical data
ATC code
  • none
Identifiers
  • 10-{2-[(RS)-1-Methylpiperidin-2-yl]ethyl}-2-(methylsulfonyl)-10H-phenothiazine
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.035.274 Edit this at Wikidata
Chemical and physical data
FormulaC21H26N2O2S2
Molar mass402.57 g·mol−1
3D model (JSmol)
  • O=S(=O)(c2cc1N(c3c(Sc1cc2)cccc3)CCC4N(C)CCCC4)C
  • InChI=1S/C21H26N2O2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)26-21-11-10-17(15-19(21)23)27(2,24)25/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 checkY
  • Key:FLGCRGJDQJIJAW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)
Close

Synthesis

Synthesis of sulforidazine

Sulforidazine can be synthesized starting 2-bromo-2'-amino-4'-methylsulfonyl-diphenyl sulfide (1).[2][3][4] Acetylation produces 2-bromo-2'-acetamino-4'-methylsulphonyl diphenylsulfide (2), which is then alkylated with 2-(2-chloroethyl)-1-methylpiperidine (3). Deacylation followed by a copper-catalyzed ring-formation reaction produces sulforidazine.

References

Related Articles

Wikiwand AI