TACC3

Transforming acidic coiled-coil-containing protein 3 is a protein that in humans is encoded by the TACC3 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesTACC3, ERIC-1, ERIC1, transforming acidic coiled-coil containing protein 3, Tacc4, maskin

External IDsOMIM: 605303; MGI: 1341163; HomoloGene: 81618; GeneCards: TACC3; OMA:TACC3 - orthologs

Chr.Chromosome 4 (human)^[1]

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TACC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LPZ, 4PKY
Identifiers
Aliases	TACC3, ERIC-1, ERIC1, transforming acidic coiled-coil containing protein 3, Tacc4, maskin
External IDs	OMIM: 605303; MGI: 1341163; HomoloGene: 81618; GeneCards: TACC3; OMA:TACC3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 1,712,858 bp[1] End 1,745,171 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B2 Start 33,658,128 bp[2] End 33,678,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte ventricular zone secondary oocyte right testis left testis granulocyte monocyte blood ganglionic eminence gonad Top expressed in primary oocyte ventricular zone yolk sac epiblast tail of embryo primitive streak spermatocyte genital tubercle maxillary prominence embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule cytoskeleton spindle pole spindle cytoskeleton microtubule organizing center cytosol mitotic spindle Biological process cell population proliferation cerebral cortex development metaphase regulation of mitotic spindle organization microtubule cytoskeleton organization involved in mitosis cell cycle cell division microtubule cytoskeleton organization mitotic spindle organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10460 21335 Ensembl ENSG00000013810 ENSMUSG00000037313 UniProt Q9Y6A5 Q9JJ11 RefSeq (mRNA) NM_006342 NM_001040435 NM_011524 NM_001310541 RefSeq (protein) NP_006333 n/a Location (UCSC) Chr 4: 1.71 – 1.75 Mb Chr 5: 33.66 – 33.68 Mb PubMed search [3] [4]
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The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice.^[6]