TAF1B

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.[5][6]

AliasesTAF1B, MGC:9349, RAF1B, RAFI63, SL1, TAFI63, TATA-box binding protein associated factor, RNA polymerase I subunit B
End9,934,416 bp[1]
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TAF1B
Identifiers
AliasesTAF1B, MGC:9349, RAF1B, RAFI63, SL1, TAFI63, TATA-box binding protein associated factor, RNA polymerase I subunit B
External IDsOMIM: 604904; MGI: 109577; HomoloGene: 31331; GeneCards: TAF1B; OMA:TAF1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005680
NM_001318976
NM_001318977

NM_020614

RefSeq (protein)

NP_001305905
NP_001305906
NP_005671

NP_065639

Location (UCSC)Chr 2: 9.84 – 9.93 MbChr 12: 24.55 – 24.61 Mb
PubMed search[3][4]
Wikidata
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Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.[6]

Interactions

TAF1B has been shown to interact with RRN3.[7]

References

Further reading

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