TAF1B
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.[5][6]
AliasesTAF1B, MGC:9349, RAF1B, RAFI63, SL1, TAFI63, TATA-box binding protein associated factor, RNA polymerase I subunit B
External IDsOMIM: 604904; MGI: 109577; HomoloGene: 31331; GeneCards: TAF1B; OMA:TAF1B - orthologs
Function
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.[6]