TAN-821

Pharmaceutical compound From Wikipedia, the free encyclopedia

TAN-821 is an opioid drug which was originally reported as an agonist for the putative ε-opioid receptor, however this is now thought not to be a separate opioid receptor in its own right but is more likely a heteromer made from hybridisation of known opioid receptor subunits. It has subsequently been shown to have potent affinity for the kappa opioid receptor.[1][2][3][4][5]

PubChem CID
ChemSpider
ChEMBL
FormulaC32H36N2O4
Quick facts Identifiers, PubChem CID ...
TAN-821
Identifiers
  • (1R,2S,6R,14R,15R,16S)-5-(cyclopropylmethyl)-11,15-dihydroxy-N-methyl-N-(2-phenylethyl)-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,18-tetraene-16-carboxamide
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC32H36N2O4
Molar mass512.650 g·mol−1
3D model (JSmol)
  • CN(CCC1=CC=CC=C1)C(=O)[C@H]2C[C@@]34C=C[C@@]2([C@H]5[C@@]36CCN([C@@H]4CC7=C6C(=C(C=C7)O)O5)CC8CC8)O
  • InChI=1S/C32H36N2O4/c1-33(15-11-20-5-3-2-4-6-20)28(36)23-18-30-12-13-32(23,37)29-31(30)14-16-34(19-21-7-8-21)25(30)17-22-9-10-24(35)27(38-29)26(22)31/h2-6,9-10,12-13,21,23,25,29,35,37H,7-8,11,14-19H2,1H3/t23-,25-,29-,30-,31+,32-/m1/s1
  • Key:XTSYSSUSRFOCHS-ZZVPPEEFSA-N
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