TAX1BP3

TAX1BP3
Identifiers
Aliases	TAX1BP3, TIP-1, TIP1, Tax1 binding protein 3
External IDs	OMIM: 616484; MGI: 1923531; GeneCards: TAX1BP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KG2, 2L4S, 2L4T, 2VZ5, 3GJ9, 3SFJ, 4E3B, 4NNL, 4NNM
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,668,679 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	73,073,988 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; apex of heart; ; mucosa of esophagus; ; canal of the cervix; ; mucosa of transverse colon; ; ectocervix; ; vagina; ; right auricle of heart; ; left ventricle; ; left coronary artery;
	Top expressed in
	ileum; ; jejunum; ; stomach; ; blastocyst; ; colon; ; urinary bladder; ; yolk sac; ; neural tube; ; white adipose tissue; ; lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	beta-catenin binding; protein C-terminus binding; protein binding;
Cellular component	cytoplasm; cytosol; plasma membrane; extracellular exosome; membrane; nucleus; fibrillar center; actin cytoskeleton; intracellular membrane-bounded organelle;
Biological process	negative regulation of Wnt signaling pathway; negative regulation of protein localization to cell surface; regulation of Wnt signaling pathway; Wnt signaling pathway; Rho protein signal transduction; activation of GTPase activity; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	30851
	76281
	ENSG00000213977
	ENSMUSG00000040158
	O14907
	Q9DBG9
	NM_014604; NM_001204698
	NM_029564
	NP_001191627; NP_055419
	NP_083840
	Wikidata
View/Edit Human	View/Edit Mouse

Tax1-binding protein 3 is a protein that in humans is encoded by the TAX1BP3 gene.^[5]^[6]^[7] This name is in reference to the Tax1 protein of the Human T-cell Lymphotropic Virus (HTLV) which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by co-IP. TIP1, as it is also known, is a PDZ domain containing protein. However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain. This has led to the speculation that TIP1 acts as an inhibitor, either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the cytosol.