TDI-11861

CAS Number

• 2857049-72-8

PubChem CID

• 166101565

FormulaC₂₂H₂₅ClF₂N₆O₃

Molar mass494.93 g·mol⁻¹

TDI-11861

Identifiers
IUPAC name [(3R)-4-[2-[2-[[3-(2-amino-6-chloropyrimidin-4-yl)-1-(difluoromethyl)pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol
CAS Number	2857049-72-8
PubChem CID	166101565
Chemical and physical data
Formula	C22H25ClF2N6O3
Molar mass	494.93 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1COC[C@H](N1CCOC2=CC=CC=C2CC3=CN(N=C3C4=CC(=NC(=N4)N)Cl)C(F)F)CO
InChI InChI=1S/C22H25ClF2N6O3/c23-19-10-17(27-22(26)28-19)20-15(11-31(29-20)21(24)25)9-14-3-1-2-4-18(14)34-8-6-30-5-7-33-13-16(30)12-32/h1-4,10-11,16,21,32H,5-9,12-13H2,(H2,26,27,28)/t16-/m1/s1 Key:XVGSKZXXLKUEIO-MRXNPFEDSA-N

TDI-11861 is a chemical compound which acts as a potent ^[1] and selective inhibitor of soluble adenylyl cyclase (sAC).^[2] In animal studies it reversibly inhibits sperm motility, producing temporary infertility without hormonal side effects. While TDI-11861 is at an early developmental stage and is unlikely to be developed for medical uses in humans itself, it represents an important proof of concept which may potentially lead to the development of future male contraceptive drugs.^[3][4]