TFCP2

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.^[5][6]

AliasesTFCP2, LBP1C, LSF, LSF1D, SEF, TFCP2C, transcription factor CP2

External IDsOMIM: 189889; MGI: 98509; HomoloGene: 4134; GeneCards: TFCP2; OMA:TFCP2 - orthologs

Chr.Chromosome 12 (human)^[1]

End51,173,135 bp^[1]

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TFCP2
Identifiers
Aliases	TFCP2, LBP1C, LSF, LSF1D, SEF, TFCP2C, transcription factor CP2
External IDs	OMIM: 189889; MGI: 98509; HomoloGene: 4134; GeneCards: TFCP2; OMA:TFCP2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12-q13.13 Start 51,093,656 bp[1] End 51,173,135 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 56.33 cM Start 100,395,893 bp[2] End 100,449,889 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus superficial temporal artery ventricular zone monocyte ganglionic eminence granulocyte rectum gastrocnemius muscle gonad islet of Langerhans Top expressed in neural layer of retina pineal gland genital tubercle tail of embryo ventricular zone perirhinal cortex renal corpuscle entorhinal cortex right kidney neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein C-terminus binding protein binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding transcription factor binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleoplasm cytosol nucleus protein-containing complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II mRNA transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7024 21422 Ensembl ENSG00000135457 ENSMUSG00000009733 UniProt Q12800 Q9ERA0 RefSeq (mRNA) NM_005653 NM_001173452 NM_001173453 NM_001289603 NM_033476 NM_001355497 RefSeq (protein) NP_001166923 NP_001166924 NP_005644 NP_001276532 NP_258437 NP_001342426 Location (UCSC) Chr 12: 51.09 – 51.17 Mb Chr 15: 100.4 – 100.45 Mb PubMed search [3] [4]
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TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1.^[7] LSF also acts as an oncogene in hepatocellular carcinoma.^[8] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).^[9]

Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.^[8][10] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death.^[8][10][11]