TFDP2

Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene that dimerises with E2F, a key transcriptional activator involved in the regulation of the cell cycle.^[5][6][7]

AliasesTFDP2, DP2, transcription factor Dp-2

External IDsOMIM: 602160; MGI: 107167; GeneCards: TFDP2

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 3 (human)^[1]

Quick facts Identifiers, Aliases ...

TFDP2
Identifiers
Aliases	TFDP2, DP2, transcription factor Dp-2
External IDs	OMIM: 602160; MGI: 107167; GeneCards: TFDP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CF7
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q23 Start 141,944,428 bp[1] End 142,149,544 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 96,196,275 bp[2] End 96,323,646 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon left testis right testis ventricular zone bone marrow cell thymus ganglionic eminence gonad epithelium of colon olfactory zone of nasal mucosa Top expressed in blood otic vesicle myocardium of ventricle tibialis anterior muscle interventricular septum hand tail of embryo vastus lateralis muscle genital tubercle Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription factor binding protein binding transcription coregulator activity protein domain specific binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex nucleoplasm mitochondrion RNA polymerase II transcription regulator complex Biological process regulation of transcription by RNA polymerase II cell cycle negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated mitotic cell cycle DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest development of the heart transcription, DNA-templated positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of transcription involved in G1/S transition of mitotic cell cycle transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of G0 to G1 transition regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 7029 211586 Ensembl ENSG00000114126 ENSMUSG00000032411 UniProt Q14188 Q64163 RefSeq (mRNA) NM_001178138 NM_001178139 NM_001178140 NM_001178141 NM_001178142 NM_006286 NM_001375756 NM_001375773 NM_001375774 NM_001375775 NM_001375776 NM_001375778 NM_001375779 NM_001375780 NM_001184706 NM_001184708 NM_001184709 NM_001184710 NM_001184711 NM_178667 RefSeq (protein) NP_001171609 NP_001171610 NP_001171611 NP_001171612 NP_001171613 NP_006277 NP_001362685 NP_001362702 NP_001362703 NP_001362704 NP_001362705 NP_001362707 NP_001362708 NP_001362709 n/a Location (UCSC) Chr 3: 141.94 – 142.15 Mb Chr 9: 96.2 – 96.32 Mb PubMed search [3] [4]
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