TH1L

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Negative elongation factor C/D is a protein that in humans is encoded by the TH1L gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesNELFCD, NELF-C, NELF-D, TH1, TH1L, HSPC130, negative elongation factor complex member C/D
Quick facts NELFCD, Available structures ...
NELFCD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNELFCD, NELF-C, NELF-D, TH1, TH1L, HSPC130, negative elongation factor complex member C/D
External IDsOMIM: 605297; MGI: 1926424; HomoloGene: 9496; GeneCards: NELFCD; OMA:NELFCD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016397
NM_198976

NM_020580

RefSeq (protein)

NP_945327

NP_065605

Location (UCSC)Chr 20: 58.98 – 59 MbChr 2: 174.26 – 174.27 Mb
PubMed search[3][4]
Wikidata
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Function

The NELF[clarification needed] complex of proteins interacts with the DSIF[clarification needed] protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.[7]

Interactions

TH1L has been shown to interact with:

References

Further reading

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