TLL2

Tolloid-like protein 2 is a protein that in humans is encoded by the TLL2 gene.^[5][6]

AliasesTLL2, tolloid like 2

External IDsOMIM: 606743; MGI: 1346044; HomoloGene: 56545; GeneCards: TLL2; OMA:TLL2 - orthologs

Chr.Chromosome 10 (human)^[1]

End96,513,926 bp^[1]

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TLL2
Identifiers
Aliases	TLL2, tolloid like 2
External IDs	OMIM: 606743; MGI: 1346044; HomoloGene: 56545; GeneCards: TLL2; OMA:TLL2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 96,364,608 bp[1] End 96,513,926 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 41,071,192 bp[2] End 41,195,274 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell gonad apex of heart testicle left ventricle Brodmann area 23 right ventricle C1 segment middle temporal gyrus muscle of thigh Top expressed in embryo tail of embryo esophagus stria vascularis mesencephalon ovary More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding zinc ion binding peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity metal ion binding serine-type endopeptidase activity Cellular component extracellular region Biological process multicellular organism development cell differentiation extracellular matrix disassembly negative regulation of skeletal muscle tissue growth proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7093 24087 Ensembl ENSG00000095587 ENSMUSG00000025013 UniProt Q9Y6L7 Q9WVM6 RefSeq (mRNA) NM_012465 NM_011904 RefSeq (protein) NP_036597 NP_036034 Location (UCSC) Chr 10: 96.36 – 96.51 Mb Chr 19: 41.07 – 41.2 Mb PubMed search [3] [4]
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This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.^[6]